A-04 Acute Sports-Related Concussion Associations Between Cognitive Symptoms, Memory Performance, and Default Mode Network Hub Connectivity

Abstract Purpose: Disruptions in cognitive performance are commonly reported after a sports-related concussion (SRC) and may be related to brain network changes, particularly within the default mode (DMN). Since well-connected regions across networks (hubs) play an important role organization, we hypothesize that DMN hubs will disrupted SRC associated with symptoms performance. Methods: We collected resting-state fMRI, symptoms, data from 44 student-athletes at baseline, SRC, recovery. Participation coefficient defined for each athlete. compared changes functional connectivity between non-hubs remaining networks. used linear regression examine relationship connectivity, while controlling history. Results: Functional increased baseline post-injury decreased recovery, but not levels. Post-injury was visual memory cingulo-opercular, salience, somatomotor, post-injury. Cognitive were non-hubs. Conclusions: Self-reported hub connectivity. This suggest decrease efficiency provide insight into compensation during task